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By fragment screening using x-ray crystallography we identified four ligands revealing ligand-binding sites in conserved interfaces between SARS-CoV-2 nsp10 and nsp14/nsp16. The nsp14/10 interaction is weak and therefore could be disrupted by small molecules. In a collaborative effort, the Lund Protein Production Platform (LP3), the FragMAX platform at the BioMAX beamline of the MAX IV laboratory,

https://www.lp3.lu.se/article/fragmax-library-identifies-ligand-binding-sites-nsp10-and-nsp1416-interfaces-sars-cov-2 - 2025-10-03

The new protein production platform will start in the beginning 2022 and is a co-operation between five Swedish universities. A new nationally distributed infrastructure - Protein Production Sweden or Proteinproduktion Sverige (PPS) in Swedish, will start up in the beginning of 2022. This is made possible thanks to a five-year-grant (until 2026) from the Swedish Research Council. Together, five un

https://www.lp3.lu.se/article/new-national-infrastructure-protein-production-sweden-pps - 2025-10-03

LP3 extends its portfolio of machines available for biophysical analysis by welcoming the OMNISEC system from Malvern Panalytical. Thanks to a grant from Olle Engkvisits foundation to Prof. Anders Malmström (Experimental Medical Sciences, Lund University), we now host a state of the art multi-detection size exclusion chromatography (SEC) system: OMNISEC. The OMNISEC system is now available to user

https://www.lp3.lu.se/article/now-lp3-absolute-molecular-weight-determination-proteins - 2025-10-03

Wolfgang Knecht, head of LP3 presented the capabilities of LP3 in biophysics and protein structure determination at the first Swedish national PI-meeting in Biochemistry, Biophysics and Molecular Biology (external webpage). The meeting was jointly organized by the Swedish Society for Biochemistry, Biophysics and Molecular Biology, SFBBM(external webpage, in Swedish) and the Swedish National Commit

https://www.lp3.lu.se/article/lp3-presented-swedish-national-pi-meeting-biochemistry-biophysics-and-molecular-biology - 2025-10-03

To strengthen the engagement of the Swedish scientific community in ESS, Sweden has now officially become part of the ESS in-kind community with four projects selected by ESS and the Swedish Research Council. To strengthen the engagement of the Swedish scientific community in the European Spallation Source (ESS), Sweden has now officially become part of the ESS in-kind community with a number of c

https://www.lp3.lu.se/article/sweden-enters-kind-agreement-ess-lp3-contributes-deuteration-lab-services - 2025-10-03

The Deuteration Network (DeuNet) is an international network which aims to facilitate access to deuteration services. The Deuteration Network (DeuNet) (external webpage) is an international network of deuteration facilities and laboratories which aims to facilitate access to deuteration services and customised deuterium labelling of molecules and biomolecules for use in neutron research and in oth

https://www.lp3.lu.se/article/new-deunet-webpage-now-launched - 2025-10-03

All staff from LP3, which is one out of five nodes in the PPS national infrastructure, participated. The distributed national research infrastructure Protein Production Sweden (PPS, see external website) did meet for its second annual staff retreat at Ljunglöfska slottet in Stockholm. The 25 staff researchers of PPS attending used the two day meeting (28/29th September 2023) to discuss and reflect

https://www.lp3.lu.se/article/annual-pps-retreat-stockholm - 2025-10-03

Recently, a book chapter with protocols for the Baculovirus Expression Vector System in insect cells was published by LP3. Lund Protein Production Platform (LP3) has recently published its standard operating procedures for recombinant protein expression using the Baculovirus Expression Vector System (BEVS) in insect cells. Read the full book chapter here at Springer Link (external website)LP3 prov

https://www.lp3.lu.se/article/new-publication-about-bevs-lp3 - 2025-10-03

Members of the board and scientific committee of PPS, Sabine Suppmann and Kim Remans, respectively are among the authors of a new review in Star Protocols about expression systems for recombinant protein production. The overview is based on a survey with 60 leading experts in protein production about their experiences and practices in using different expression systems for recombinant protein prod

https://www.lp3.lu.se/article/guide-choosing-expression-system-recombinant-proteins - 2025-10-03

Lund Protein Production Platform (LP3) is featured in EUGLOHRIA Talks and EUGLOHRIA Virtual Tours approaching audiences with interactive and innovative content and an interview with the head of LP3, Dr. Wolfgang Knecht, is now available on the EUGLOHRIA homepage. The European University Alliance for Global Health – Transformation through Joint Research and Innovation Action (EUGLOHRIA, external li

https://www.lp3.lu.se/article/lund-protein-production-platform-featured-euglohria-talks-and-euglohria-virtual-tours - 2025-10-03

At the first 2024 management meeting, SciLifeLab Lund welcomed LP3 as a new local core facility. The aim of the local SciLifeLab sites in Umeå, Linköping, Gothenburg and Lund is to bring national infrastructure activities closer to the research communities at these locations, and to contribute to increased synergies and collaborations with multiple stakeholders.SciLifeLab Lund (external webpage) w

https://www.lp3.lu.se/article/lp3-newest-local-core-facility-scilifelab-lund - 2025-10-03

LP3 with Celeste Sele presented its capabilities in Protein Characterisation, Crystallisation and Structure Determination at the 35th MAX IV user meeting in Lund (external homepage). LP3 is harboring a local node of Protein Production Sweden (PPS). PPS focuses on the production and purification of (mainly) recombinant protein reagents for all Swedish researchers. The Director of PPS, Malin Bäckstr

https://www.lp3.lu.se/article/lp3-and-pps-35th-max-iv-user-meeting - 2025-10-03

LP3 is now part of "Pandemics and Alertness", a collaboration initiative for virus-related topics by Lund University Pandermics and Alertness is an interdisciplinary platform created to promote collaboration and change of information between stakeholders, researchers and experts from different disciplines, and public authorities to improve our knowledge of the impact of pandemics on the society. A

https://www.lp3.lu.se/article/pandemics-and-alertness - 2025-10-03

Together with DEMAX (see external wesite), the Lund Protein Production Platform (LP3) recently published a new protocol for the use of algal autolysate for the production of deuterium-labeled recombinant protein featuring:Continuous cultivation and autolysis of deuterated B. brauniiAutolysate used as glycerol substitute in recombinant protein productionUsing autolysate gives high protein yield and

https://www.lp3.lu.se/article/demax-and-lp3-publish-new-protocol-use-algal-autolysate-production-deuterium-labeled-recombinant - 2025-10-03

InfraLife Project Coordinator, Claire Lyons, came for a site visit at LP3 InfraLife is a national initiative to improve knowledge and availability of infrastructures and make it accessible to Life science researchers in academia, industry and health care. Read more about the visit here at InfraLife news (external webpage).  More information about InfraLife can be found on the InfraLife homepage (e

https://www.lp3.lu.se/article/visit-infralife-lp3 - 2025-10-03

The second workshop arranged by VBE researchers covered different aspects of VBE in law. Legal scholars as well as practitioners of law talked on topics such as the individual judge's approach to VBE, VBE as a critical legal threshold, the legal requirements concerning untested methods in medicine, and more. The talks are collected in this short publication.

https://www.vbe.lu.se/article/vbe-law-publication-workshop-lund - 2025-10-03

22 mars är det återigen dags för ett halvdagsseminarium i Lund om VBE inom ett specifikt verksamhetsområde. Denna gång är det miljövård som står i fokus. Vari består den evidens som policybeslut om miljön vilar på, och som ligger till grund för praktisk miljövård i våra regioner och kommuner? Hur skaffar man den nödvändiga evidensen? Hur bedömer en rättsinstans om tillräcklig evidens finns då osäk

https://www.vbe.lu.se/article/vbe-i-miljovard - 2025-10-03

Nils-Eric och Annika är intervjuade i var sin artikel om risker och beslut. Aktuellt om vetenskap & hälsa produceras som ett samarbete mellan Medicinska fakulteten vid Lunds universitet, Malmö högskola och sjukvårdsförvaltningarna inom Region Skåne. En fysisk publikation utkommer två gånger om året och artiklar publiceras fortlöpande på webbplatsen. Två av de senaste artiklarna är intervjuer med N

https://www.vbe.lu.se/article/vbeforskare-intervjuade-i-aktuellt-om-vetenskap-halsa - 2025-10-03

Three new articles from VBE researchers will soon be accessible from the VBE website: Nils-Eric Sahlin and Lena Wahlberg in Förvaltningsrättslig tidskrift, Wändi Bruine de Bruin and Baruch Fischhoff in PNAS and Wändi Bruine de Bruin, Annika Wallin et al. in Medical Decision Making. In "Om icke vedertagna behandlingsmetoder och kravet på vetenskap och beprövad erfarenhet.", published in Förvaltning

https://www.vbe.lu.se/article/recently-published-vbe-articles - 2025-10-03

European Comission President Jean-Claude Juncker has renewed the European Group on Ethics in Science and New Technologies, EGE, and has appointed 15 distuinguished scholars as members. One of these is our own Nils-Eric Sahlin. In a short interview (in Swedish) with the Lund University communicator Johanna Sandahl, Nils-Eric describes the role of EGE and his own role within the group:Vilken roll ha

https://www.vbe.lu.se/article/nils-eric-sahlin-appointed-member-ege - 2025-10-03